Learn about the effects of combining NMN and resveratrol supplements, how to choose the best brands, and what doses you should take.
Aging is an inseparable part of human life, but it doesn’t have to be accompanied by a sudden decline in health. Recent scientific discoveries on longevity supplements NMN (nicotinamide mononucleotide) and resveratrol have sparked hope that we can mitigate various age-related diseases.
Popularized by Harvard researcher Dr. David Sinclair, these supplements fuel the production and usage of NAD+ (Nicotinamide Adenine Dinucleotide). The decrease of this coenzyme is linked to low energy levels, cognitive decline, cardiovascular issues, and various other diseases. When taken together, NMN and resveratrol have a powerful effect on fighting them.
Out of all the processes happening in the human body, energy production might be the most important. The chemical energy stored in food is used by mitochondria to produce adenosine triphosphate (ATP) molecules that power cells.
Without enough energy, cells cannot repair themselves from disease, express genes, and perform other vital functions. In simpler terms, the body starts to age faster. This process is dependent on Nicotinamide Adenine Dinucleotide (NAD), which comes in two forms.
The oxidized NAD+ form accepts electrons, and the reduced form, NADH, transfers them to the electron transport chain in the mitochondria. The constant interplay of these two NAD forms creates an energy production cycle that fuels the human body.
Without sufficient NAD levels, cells cannot produce energy effectively, and without energy, the body starts to show signs of aging faster. This is also supported by the fact that NAD levels decline as we age (1).
Some foods, especially those rich in Vitamin B3, such as fish, lean meats, whole grains, and various vegetables, can support NAD production in our bodies. However, it is doubtful that anyone can consume enough natural foods to keep up with the NAD decline that comes with aging.
Besides, various digestive issues, lifestyle factors, and variations in food quality further complicate our ability to supplement NAD from food. The only viable option is to look for additional NAD sources. That’s where NMN and resveratrol supplements come in.
Nicotinamide mononucleotide (NMN) is considered a direct precursor to NAD+, as it boosts specific protein transporters and other precursors important for NAD+ production (2). As a result, NMN supplements improve cellular health and overall well-being through a few important mechanisms.
Studies on animals and ongoing trials on humans have shown that these effects have a positive impact on boosting cognitive function (3), cardiovascular health (4), and physical performance (5). However, taking NMN supplements alone, while beneficial, does not necessarily translate into the desired benefits if NAD+ isn’t used by the body in the most beneficial way.
The same mechanisms that benefit plants are sometimes beneficial to humans and animals. Such is the case with resveratrol. It is a type of polyphenol, a substance found in various plants and berries responsible for their regenerative features.
Resveratrol is usually concentrated in the outer skin of fruits such as red grapes and helps them recover from injuries or infections. Trans-resveratrol, a more bioactive form, is used in various supplements tested on animals and humans to help build antioxidant and anti-inflammatory properties (6).
Most of the benefits of resveratrol are due to the fact that it activates sirtuins. These are the same NAD-dependent proteins whose production NMN supplements promote. The resveratrol molecule directly promotes sirtuin activation by binding to these proteins and enhancing their enzymatic activity.
Similar to how plants build their molecular defenses when infected, the human body calls on sirtuins to aid in recovery. In both cases, resveratrol plays a crucial role in sirtuin activation. Given that the organism has sufficient NAD levels, resveratrol can bring various benefits.
Many of the benefits of NMN and resveratrol supplements overlap, not because they might interfere with each other’s functioning, but because they work synergistically. NMN boosts the production of NAD, while resveratrol directs it to activate sirtuins, leading to more pronounced health benefits.
This is not to say that taking NMN or resveratrol alone would not have health benefits. NMN is likely to be beneficial on its own, but the benefits, especially in terms of energy boost, might not be as noticeable. Similarly, resveratrol on its own might not provide as many health benefits if the body lacks sufficient NAD resources.
Studies have already shown a measurable effect of these synergistic properties. The specifics of the functioning mechanisms are still debated, but it is agreed that resveratrol supplementation enhances the benefits of NMN and vice versa (7).
Dr. David Sinclair has also commented in various less academic formats, such as podcasts (8), that his own supplementation routine includes both resveratrol and NMN precisely due to their synergies in boosting NAD and directing it to activate sirtuins.
The single most important factor when choosing NMN and resveratrol supplements is purity. The problem is that every brand will tell you that they have the highest purity and do not mix in other ingredients to lower costs.
Impure supplements are not only less effective and provide inconsistent dosing, but they can also cause health concerns, such as allergies, due to unknown additives used. The only way you can trust a brand’s word is by referring to third-party certifications that have tested the supplements to ensure that purity is as stated.
Good Manufacturing Practices (GMP) standards imposed by the World Health Organization cover most of these requirements. Quality brands will also provide various quality reports from third-party laboratories.
Combining NMN and resveratrol might complicate this process and make the dosing of supplements more difficult. That’s why brands that sell them in bundles of different capsules should be preferred. Sublingual or powder forms of NMN and resveratrol supplements are possible but less studied and tested by users.
Once we account for all the requirements, not many brands remain worthy of trying out. PartiQlar and Hello100 offer NMN and resveratrol bundles worth recommending. Depending on the current deals they have, you should choose one or the other.
PartiQlar is a longevity supplement brand that, among many other offerings, provides 99% pure resveratrol and NMN bundles. The supplements are third-party tested with all necessary certifications and are manufactured in United States FDA and NSF registered facilities.
Resveratrol and NMN come in bundles of separate capsules. The more bundles you buy, the better deal you’ll get, with the 12-month supply pack saving you 47%. There are also subscription deals that can save you 15% off the final price if you order at least every six months.
The research-focused team at Hello100 is driven to provide the best healthy aging supplements and other innovations. They are currently developing science-based methods of tracking your NMN product results. So, if not for their supplements, Hello100 is definitely worth following for their scientific initiatives and blog.
Their NMN and resveratrol supplements are nothing less than excellent. Made in the USA with all the third-party certifications you would expect, you can trust the purity of their supplements. There are also bundle deals and free shipping within the USA available.
While human trials of NMN and resveratrol are still ongoing, safe dosages can already be determined for use. Taking them together is generally safe and shouldn’t impact the way you take them individually.
It’s best to take them after a meal early in the day. That way, the energy boost is least likely to disrupt your sleep cycle and will make it easier to follow the changes in your body. Keeping track of your body is crucial, as you can later increase or decrease each of the substances to maximize the benefits.
NMN and resveratrol work together to boost cellular energy production, which is one of the most crucial factors in preserving our well-being as we age. Choose trusted brands with high purity and manufacturing standards to harness the full power of the NMN and resveratrol combination.
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